Publicação
Papiloma invertido das fossas nasais e seios perinasais : revisão sistemática
| Resumo: | Inverted Papilloma is a benign tumour that arises in the nasal cavity and paranasal sinuses, and that despite being rare, shows a challenging biologic behaviour due to: its local aggressiveness, a high recurrence rate, and its association with a malignant transformation. This study was motivated by the rarity of the disease and by its behaviour and it aims at reviewing the existing literature on the subject. Although the disease's etiology is not entirely known, it is thought that Human Papilloma Virus (HPV) is involved, despite the fact that the molecular basis of this disease have not been clarified yet. The diagnosis is anatomopathological and imaging-based, and CT scan, MRI and nasal endoscopy may be used. This review includes the definition of Inverted Papilloma, a description of its historic data, epidemiology, histopathology and etiology. Inverted Papilloma's biologic behaviour, molecular basis and clinical presentation are also approached. Finally, diagnosis, staging and treatment are also discussed. The treatment of this type of lesion still remains a clinical challenge to otolaryngologists. However, there is certainty about using surgery as a first choice and on the fact that a long-term follow-up is necessary for this kind of patients. |
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| Autores principais: | Tomás, Ana Rita Vieira Sousa |
| Assunto: | Papiloma invertido Fossas nasais Seios perinasais Vírus do papiloma humano (VPH) |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Inverted Papilloma is a benign tumour that arises in the nasal cavity and paranasal sinuses, and that despite being rare, shows a challenging biologic behaviour due to: its local aggressiveness, a high recurrence rate, and its association with a malignant transformation. This study was motivated by the rarity of the disease and by its behaviour and it aims at reviewing the existing literature on the subject. Although the disease's etiology is not entirely known, it is thought that Human Papilloma Virus (HPV) is involved, despite the fact that the molecular basis of this disease have not been clarified yet. The diagnosis is anatomopathological and imaging-based, and CT scan, MRI and nasal endoscopy may be used. This review includes the definition of Inverted Papilloma, a description of its historic data, epidemiology, histopathology and etiology. Inverted Papilloma's biologic behaviour, molecular basis and clinical presentation are also approached. Finally, diagnosis, staging and treatment are also discussed. The treatment of this type of lesion still remains a clinical challenge to otolaryngologists. However, there is certainty about using surgery as a first choice and on the fact that a long-term follow-up is necessary for this kind of patients. |
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