Detalhes bibliográficos
| Resumo: | Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1-2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans. |
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| Autores principais: | Sørensen, D. M. |
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| Outros Autores: | Bostock, H.; Abrahao, A.; Alaamel, A.; Alaydin, H. C.; Ballegaard, M.; Boran, E.; Cengiz, B.; Carvalho, Mamede; Dunker, Ø.; Fuglsang-Frederiksen, A.; Graffe, C. C.; Jones, K. E.; Kallio, M.; Kalra, S.; Krarup, C.; Krøigård, T.; Liguori, R.; Lupescu, T.; Maitland, S.; Matamala, J. M.; Moldovan, M.; Moreno-Roco, J.; Nilsen, K. B.; Phung, L.; Santos, M. O.; Themistocleous, A. C.; Uysal, H.; Vacchiano, V.; Whittaker, R. G.; Zinman, L.; Tankisi, H. |
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| Assunto: | CMAP Scan MScanFit MUNE Motor unit number estimation Repeatability |
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| Ano: | 2023 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade de Lisboa |
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| Idioma: | inglês |
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| Origem: | Repositório da Universidade de Lisboa |
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