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Role of lipids in killing mycobacteria by macrophages

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Detalhes bibliográficos
Resumo:We have shown that several lipids can modulate the macrophage innate immune response against mycobacteria and enhance their killing. Since NF-kappa B is required for mycobacterial killing, we tested the ability of lipids to activate NF-kappa B in uninfect. - Alexander von Humboldt Foundation ; EMBO ; DFG [SPP-1267]; Fundacao para a Ciencia e a tecnologia (FCT) [PPCDT/BIA-BCM/55327/2007]. - We are grateful to David Liebl for critical reading of this manuscript. We would also like to thank Stefan Terjung at the Advanced Light Microscopy Facility and Andy Riddell at the Flow Cytometry Facility (EMBL, Heidelberg) for excellent technical assista
Autores principais:Gutierrez, Maximiliano Gabriel
Outros Autores:Gonzalez, Alexis Perez; Anes, Elsa; Griffiths, Gareth
Assunto:Cell Biology Microbiology
Ano:2009
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso a metadados
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa
Descrição
Resumo:We have shown that several lipids can modulate the macrophage innate immune response against mycobacteria and enhance their killing. Since NF-kappa B is required for mycobacterial killing, we tested the ability of lipids to activate NF-kappa B in uninfect. - Alexander von Humboldt Foundation ; EMBO ; DFG [SPP-1267]; Fundacao para a Ciencia e a tecnologia (FCT) [PPCDT/BIA-BCM/55327/2007]. - We are grateful to David Liebl for critical reading of this manuscript. We would also like to thank Stefan Terjung at the Advanced Light Microscopy Facility and Andy Riddell at the Flow Cytometry Facility (EMBL, Heidelberg) for excellent technical assista