Publicação
Doença celíaca num doente com síndrome poliglandular autoimune tipo III : caso clínico
| Resumo: | Polyglandular Autoimmune Syndromes (PGAS) are characterized by the association between autoimmune endocrine and non-endocrine diseases. There are three subtypes of PGAS. Type III is frequently wrongly diagnosed as type II (the most common). PGAS III diagnosis relies upon the coexistence of autoimmune thyroiditis (AT), and other autoimmune endocrine diseases, except autoimmune adrenal insufficiency, hypoparathyroidism and chronic mucocutaneous candidiasis. In this article, we describe a case report of a patient with type III PGAS, namely type 1 diabetes and Hashimoto’s thyroiditis (HT), whose diagnosis was made 17 years apart, and more recently Celiac Disease (CD), on the course of an anemia investigation. CD is a non-endocrine autoimmune disease that may also be found in PGAS. Studies reveal a strong association between CD and type 1 diabetes, and this cluster of autoimune diseases is related with HLA (human leukocyte antigen) class II. Thus, this case report highlights the importance of screening non-endocrine diseases in patients with endocrine autoimmune diseases, since this changes the clinical and therapeutic approaches. |
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| Autores principais: | Valadão, Ivone Emília Melo |
| Assunto: | Doença Celíaca Síndromes poliglandulares autoimunes |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Polyglandular Autoimmune Syndromes (PGAS) are characterized by the association between autoimmune endocrine and non-endocrine diseases. There are three subtypes of PGAS. Type III is frequently wrongly diagnosed as type II (the most common). PGAS III diagnosis relies upon the coexistence of autoimmune thyroiditis (AT), and other autoimmune endocrine diseases, except autoimmune adrenal insufficiency, hypoparathyroidism and chronic mucocutaneous candidiasis. In this article, we describe a case report of a patient with type III PGAS, namely type 1 diabetes and Hashimoto’s thyroiditis (HT), whose diagnosis was made 17 years apart, and more recently Celiac Disease (CD), on the course of an anemia investigation. CD is a non-endocrine autoimmune disease that may also be found in PGAS. Studies reveal a strong association between CD and type 1 diabetes, and this cluster of autoimune diseases is related with HLA (human leukocyte antigen) class II. Thus, this case report highlights the importance of screening non-endocrine diseases in patients with endocrine autoimmune diseases, since this changes the clinical and therapeutic approaches. |
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