Publicação
Feline hyperthyroidism : a longitudinal comparative study of patients in the presence or absence of concurrent chronic kidney disease
| Resumo: | ABSTRACT - Feline Hyperthyroidism: a longitudinal comparative study of patients in the presence or absence of concurrent chronic kidney disease - Feline hyperthyroidism is the most common endocrinopathy of the domestic cat and is caused by the multi-systemic effects of increased circulating concentrations of thyroid hormones T3 and T4. Geriatric feline patients also frequently suffer from concurrent chronic kidney disease, often only noticeable when thyrotoxicosis is addressed and the glomerular filtration rate diminishes, allowing the diagnosis of this underlying disease. The prediction or detection of underlying renal disease is vital for the establishment of appropriate treatment and avoiding further renal damage. Laboratorial screenings are seldom valuable in its diagnosis, as hyperthyroidism “masks” many of the alterations associated with the renal disorder. This study shows that serum concentrations of urea may be used as a diagnostic indicator of chronic kidney disease, with a 70% sensitivity. Determination of a cut-off value of 11.6 mmol/L and 135.5 μmol/L for reference levels of serum concentrations of urea and creatinine, respectively, proved to significantly beneficial as diagnostic indicators of underlying chronic kidney disease, with a sensitivity and specificity of 80% and 92%, correspondingly, for the cut-off value of serum urea and 30% and 100%, correspondingly, for the cut-off value of serum creatinine. These findings may represent the solution for the diagnostic challenge that these patients represent. |
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| Autores principais: | Oswald, Lara Andreia Silva |
| Assunto: | Feline hyperthyroidism Chronic kidney disease Indicator Urea Creatinine Hipertiroidismo felino Doença renal crónica Indicador Ureia Creatinina |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | ABSTRACT - Feline Hyperthyroidism: a longitudinal comparative study of patients in the presence or absence of concurrent chronic kidney disease - Feline hyperthyroidism is the most common endocrinopathy of the domestic cat and is caused by the multi-systemic effects of increased circulating concentrations of thyroid hormones T3 and T4. Geriatric feline patients also frequently suffer from concurrent chronic kidney disease, often only noticeable when thyrotoxicosis is addressed and the glomerular filtration rate diminishes, allowing the diagnosis of this underlying disease. The prediction or detection of underlying renal disease is vital for the establishment of appropriate treatment and avoiding further renal damage. Laboratorial screenings are seldom valuable in its diagnosis, as hyperthyroidism “masks” many of the alterations associated with the renal disorder. This study shows that serum concentrations of urea may be used as a diagnostic indicator of chronic kidney disease, with a 70% sensitivity. Determination of a cut-off value of 11.6 mmol/L and 135.5 μmol/L for reference levels of serum concentrations of urea and creatinine, respectively, proved to significantly beneficial as diagnostic indicators of underlying chronic kidney disease, with a sensitivity and specificity of 80% and 92%, correspondingly, for the cut-off value of serum urea and 30% and 100%, correspondingly, for the cut-off value of serum creatinine. These findings may represent the solution for the diagnostic challenge that these patients represent. |
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