Publicação
Shifting Networks in functional Magnetic Resonance Imaging (MRI) : brain network properties derived comparing resting state versus passive viewing
| Resumo: | Most Functional Magnetic Resonance Imaging (fMRI) studies with the goal of understanding the Functional Connectivity (FC) of the brain have applied Resting-State fMRI to study connectivity between different brain regions. With the objective of applying a new method, we developed a novel approach using a passive task-based fMRI acquisition created to induce the shifting of brain networks, and thus increase between network connectivity. This approach consists of an array of images and stimuli created to excite specific networks and thus to enhance Functional Connectivity. We applied this novel paradigm in both typically developing youth and youth with Anorexia Nervosa (AN). AN is a severe psychological disorder characterized by an obsessive desire to lose weight by refusing to eat. We hypothesised that, using only healthy participants, viewing the Passive-Task will create a stronger shifts between different networks, translated in a higher FC between regions of distinct networks, when compared to the shift of networks at Resting-State. Also we hypothesised that no significant differences within the connectivity of regions of the same networks would be found between Resting-State and Passive-Task. Results show a greater connectivity during the Passive-Task in areas related to Executive Control, such as the insula and the Lateral Prefrontal Cortex, with areas from the Secondary Visual and Lateral Parietal Occipital networks. Higher connectivity at rest was found in the majority of the pairs of connected regions, especially related to the Cerebellar-Occipital networks. Although our results were not as hypothesised, this work proposes a new view on the use of passive viewing tasks, in the study of FC and network shifts. In the future, the goal of the task is to be used to compare FC in cases of AN with controls. |
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| Autores principais: | Dias, Laura Monteiro Rente |
| Assunto: | Ressonância Magnética Funcional Adolescência Estado de repouso Tarefa Rede neuronal Teses de mestrado - 2023 |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Most Functional Magnetic Resonance Imaging (fMRI) studies with the goal of understanding the Functional Connectivity (FC) of the brain have applied Resting-State fMRI to study connectivity between different brain regions. With the objective of applying a new method, we developed a novel approach using a passive task-based fMRI acquisition created to induce the shifting of brain networks, and thus increase between network connectivity. This approach consists of an array of images and stimuli created to excite specific networks and thus to enhance Functional Connectivity. We applied this novel paradigm in both typically developing youth and youth with Anorexia Nervosa (AN). AN is a severe psychological disorder characterized by an obsessive desire to lose weight by refusing to eat. We hypothesised that, using only healthy participants, viewing the Passive-Task will create a stronger shifts between different networks, translated in a higher FC between regions of distinct networks, when compared to the shift of networks at Resting-State. Also we hypothesised that no significant differences within the connectivity of regions of the same networks would be found between Resting-State and Passive-Task. Results show a greater connectivity during the Passive-Task in areas related to Executive Control, such as the insula and the Lateral Prefrontal Cortex, with areas from the Secondary Visual and Lateral Parietal Occipital networks. Higher connectivity at rest was found in the majority of the pairs of connected regions, especially related to the Cerebellar-Occipital networks. Although our results were not as hypothesised, this work proposes a new view on the use of passive viewing tasks, in the study of FC and network shifts. In the future, the goal of the task is to be used to compare FC in cases of AN with controls. |
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