Detalhes bibliográficos
| Resumo: | Supercritical carbon dioxide (scCO(2)) offers several attractive scenarios for the pharmaceutical processing as an alternative to aqueous and organic solvents. In this work naproxen, a widely used non steroidal anti-inflammatory drug with analgesic and anti-inflammatory properties, was chosen as a model drug. Its complexation with cyclodextrins improves the rate and extent of dissolution of the drug, increase its rate of absorption and may reduce the unpleasant side-effects of the drug. The interest in using this supercritical technology led us to develop an experimental unit for the use of supercritical CO2 as a processing medium for the complexation of naproxen with beta cyclodextrin (CD). |
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| Autores principais: | Junco, S |
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| Outros Autores: | Casimiro, T; Ribeiro, N; Da Ponte, MN; Marques, Helena |
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| Assunto: | Chemistry, Multidisciplinary Crystallography |
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| Ano: | 2002 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso a metadados |
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| Instituição associada: | Universidade de Lisboa |
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| Idioma: | inglês |
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| Origem: | Repositório da Universidade de Lisboa |
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