Publicação
2-(4 '-aminobenzenamine)-pyrimidine, a new alpha-antagonist from Autonoe madeirensis
| Resumo: | A new natural pyrimidine derivative, 2-(4'-aminobenzenamine)pyrimidine (1), was isolated from the bulbs of Autonoe madeirensis, a Hyacinthaceae of the Madeira Archipelago (Portugal) and the structure determined on the basis of spectroscopic data. As some pyrimidine compounds are important alpha(1)-adrenergic antagonists, we investigated the effect of 1 on rat vas deferens contractility induced by the alpha(1)-agonist phenylephrine. In concentrations virtually devoid of effect on the rat vas deferens contractility, 1 shifted to the right the concentration-response curves of phenylephrine without changing the maximal effect. These results provide evidence that 1 acts as an alpha(1)-adrenoceptor antagonist and suggest a competitive mechanism of action. |
|---|---|
| Autores principais: | Dias, C |
| Outros Autores: | Paulo, A; Nascimento, J; Houghton, P; Hawkes, JE; Goncalves, ML |
| Assunto: | Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy |
| Ano: | 2003 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso a metadados |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | A new natural pyrimidine derivative, 2-(4'-aminobenzenamine)pyrimidine (1), was isolated from the bulbs of Autonoe madeirensis, a Hyacinthaceae of the Madeira Archipelago (Portugal) and the structure determined on the basis of spectroscopic data. As some pyrimidine compounds are important alpha(1)-adrenergic antagonists, we investigated the effect of 1 on rat vas deferens contractility induced by the alpha(1)-agonist phenylephrine. In concentrations virtually devoid of effect on the rat vas deferens contractility, 1 shifted to the right the concentration-response curves of phenylephrine without changing the maximal effect. These results provide evidence that 1 acts as an alpha(1)-adrenoceptor antagonist and suggest a competitive mechanism of action. |
|---|