Publicação
Risco cardiovascular em doentes com lúpus eritematoso sistémico
| Resumo: | Cardiovascular diseases (CVD) are responsible for high rates of morbidity and mortality in most developed countries, particularly in Europe. Atherosclerosis, the underlying systemic disease of CVD has as pathophysiology an inflammatory / immune process that will naturally be increased in autoimmune diseases such as systemic lupus erythematosus (SLE). This study compared the cardiovascular (CV) risk of a sample of SLE patients with UK population without disease applying SCORE (Systematic Coronary Risk Evaluation). The risk was reassessed with the values of thickness of the intima - media layer of the carotid arteries and pulse wave velocity.Finally, we evaluated the relationship between cardiovascular risk and different variables specific to SLE.The sample contains 27 individuals, all females and an average age of 48.7 years.There was a lower CV risk to the UK with SCORE. The particular risk is higher with the use of supplementary tests.The use of azathioprine has shown to be associated with an increased CV risk.The combination of SCORE with diagnostic procedures is the best approach to assessing risk in this group. It is important to reflect on therapeutic with inflammatory / immune targets, to better control the cardiovascular risk in these patients. |
|---|---|
| Autores principais: | Sequeira, Ana Mafalda Silva de |
| Assunto: | Lúpus eritematoso sistémico Doenças cardiovasculares |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Cardiovascular diseases (CVD) are responsible for high rates of morbidity and mortality in most developed countries, particularly in Europe. Atherosclerosis, the underlying systemic disease of CVD has as pathophysiology an inflammatory / immune process that will naturally be increased in autoimmune diseases such as systemic lupus erythematosus (SLE). This study compared the cardiovascular (CV) risk of a sample of SLE patients with UK population without disease applying SCORE (Systematic Coronary Risk Evaluation). The risk was reassessed with the values of thickness of the intima - media layer of the carotid arteries and pulse wave velocity.Finally, we evaluated the relationship between cardiovascular risk and different variables specific to SLE.The sample contains 27 individuals, all females and an average age of 48.7 years.There was a lower CV risk to the UK with SCORE. The particular risk is higher with the use of supplementary tests.The use of azathioprine has shown to be associated with an increased CV risk.The combination of SCORE with diagnostic procedures is the best approach to assessing risk in this group. It is important to reflect on therapeutic with inflammatory / immune targets, to better control the cardiovascular risk in these patients. |
|---|