Publicação
Rearranged jatrophane-type diterpenes from Euphorbia species. Evaluation of their effects on the reversal of multidrug resistance
| Resumo: | The rearranged jatrophane-type diterpenes (1 - 3), isolated from the Me2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species. |
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| Autores principais: | Madureira, AM |
| Outros Autores: | Ferreira, MJU; Gyemant, N; Ugocsai, K; Ascenso, JR; Abreu, PM; Hohmann, J; Molnar, J |
| Assunto: | Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy |
| Ano: | 2004 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso a metadados |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | The rearranged jatrophane-type diterpenes (1 - 3), isolated from the Me2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species. |
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