Publicação
Lactato sérico como marcador de prognóstico na sépsis em idade pediátrica : artigo de revisão
| Resumo: | Sepsis is a very frequent and serious pathology defined by a systemic inflammatory response to an infection. It is still one of main causes of mortality and morbidity in the pediatric population, despite all the evolution in the last decades. Lactate levels have been used as a marker of tecidual hypoperfusion , an indicator of successful reanimation, as a marker of prognosis and as therapeutic control. This article aims to do a review of the bibliography available on the area of lactate levels as a marker of prognosis in pediatric sepsis. The search was performed using Pubmed-MEDLINE and UpToDate databases. The analysis of the blood levels of lactate, as an isolated value or as an evolving value, can determine the prognosis in children with sepsis. This value has even been used as an auxiliary in reanimation and hemodynamic stabilization, in septic shock. The level of lactate in the admission to the ICU can be essential in the stratification of the risk of mortality, because it indicates the level of tecidual hypoperfusion. In all the reviewed articles higher levels of blood lactate were associated with an increase of mortality and morbidity, and there for a worst prognosis. The most efficient method of analysis seems to be the determination of blood lactate levels every six hours through the first 48 hours of admission. Although there are innumerous potentialities to this biomarker, there are an insufficient number of studies in this area especially in the pediatric age. This means that there aren’t yet cut-off values that can be applied to the everyday clinical practice. |
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| Autores principais: | Carvalho, Ana Lúcia Cardoso |
| Assunto: | Sépsis Lactato sérico Pediatria |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Sepsis is a very frequent and serious pathology defined by a systemic inflammatory response to an infection. It is still one of main causes of mortality and morbidity in the pediatric population, despite all the evolution in the last decades. Lactate levels have been used as a marker of tecidual hypoperfusion , an indicator of successful reanimation, as a marker of prognosis and as therapeutic control. This article aims to do a review of the bibliography available on the area of lactate levels as a marker of prognosis in pediatric sepsis. The search was performed using Pubmed-MEDLINE and UpToDate databases. The analysis of the blood levels of lactate, as an isolated value or as an evolving value, can determine the prognosis in children with sepsis. This value has even been used as an auxiliary in reanimation and hemodynamic stabilization, in septic shock. The level of lactate in the admission to the ICU can be essential in the stratification of the risk of mortality, because it indicates the level of tecidual hypoperfusion. In all the reviewed articles higher levels of blood lactate were associated with an increase of mortality and morbidity, and there for a worst prognosis. The most efficient method of analysis seems to be the determination of blood lactate levels every six hours through the first 48 hours of admission. Although there are innumerous potentialities to this biomarker, there are an insufficient number of studies in this area especially in the pediatric age. This means that there aren’t yet cut-off values that can be applied to the everyday clinical practice. |
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