Publicação
Relação paraneoplásica entre a arterite de células gigantes e a eritroleucemia : estudo baseado num caso clínico
| Resumo: | Introduction: The association between vasculitis and neoplasms has been discussed for several years, and it is more frequently reported in hematological malignancies. Erythroleukemia is an uncommon form of acute myeloid leukemia. Some cases of Giant Cell Arthritis have been reported as a paraneoplastic manifestation; however, this association is not well established. Case Report: A 80-year-old man with a history of amaurosis fugax and no cardiovascular risk factors was admitted with a diagnosis of ischemic stroke. Physical examination revealed tortuous, nodular and painful superficial temporal arteries, with symmetrically reduced pulsation. He had an Hb level of 10.4g/dL, MCV 68.8fL; these findings were consistent with microcytic anemia. Hemoglobin electrophoresis detected Hemoglobin Lepore. Anti-beta-2 glycoprotein 1 antibodies were also detected. A temporal artery biopsy confirmed CGA diagnosis. The patient was treated with prednisolone 1mg/kg, with clinical improvement during follow-up. After seven months of therapy, his WBC showed persistent leukopenia with basophils and myeloblasts in the peripheral smear. Bone marrow examination was suggestive of erythroleukemia, and the patient started chemotherapy with azacitidine. Conclusion: The described case report shows a probable paraneoplastic association of GCA with erythroleukemia and discusses the pathogenic significance of Hemoglobin Lepore and the anti-beta 2 glycoprotein 1 antibody. |
|---|---|
| Autores principais: | Rodrigues, Teresa Margarida Tomaz Fernandes |
| Assunto: | Eritroleucemia Leucemia mielóide aguda Arterite de células gigantes |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Introduction: The association between vasculitis and neoplasms has been discussed for several years, and it is more frequently reported in hematological malignancies. Erythroleukemia is an uncommon form of acute myeloid leukemia. Some cases of Giant Cell Arthritis have been reported as a paraneoplastic manifestation; however, this association is not well established. Case Report: A 80-year-old man with a history of amaurosis fugax and no cardiovascular risk factors was admitted with a diagnosis of ischemic stroke. Physical examination revealed tortuous, nodular and painful superficial temporal arteries, with symmetrically reduced pulsation. He had an Hb level of 10.4g/dL, MCV 68.8fL; these findings were consistent with microcytic anemia. Hemoglobin electrophoresis detected Hemoglobin Lepore. Anti-beta-2 glycoprotein 1 antibodies were also detected. A temporal artery biopsy confirmed CGA diagnosis. The patient was treated with prednisolone 1mg/kg, with clinical improvement during follow-up. After seven months of therapy, his WBC showed persistent leukopenia with basophils and myeloblasts in the peripheral smear. Bone marrow examination was suggestive of erythroleukemia, and the patient started chemotherapy with azacitidine. Conclusion: The described case report shows a probable paraneoplastic association of GCA with erythroleukemia and discusses the pathogenic significance of Hemoglobin Lepore and the anti-beta 2 glycoprotein 1 antibody. |
|---|