Publicação
Pró-fármacos de triazenos no tratamento do cancro
| Resumo: | Cancer has great impact on the contemporary society. It causes a dramatic decrease in the quality of life of all and also affects in the people around and every day deal with this scourge. Their causes can be diverse and are sometimes unknown; their mechanisms of resistance are difficult to overcome and the effectiveness of therapies that exist so far, is still not satisfactory. The development of antitumor agents is notorious, although the perfect drug for treat this disease has not yet been discovered. There are several classes of drugs with different mechanisms of action and different acting targets that can be used concurrently to stop all pathological pathways. Prodrugs of triazenes are a promising strategy in which different approaches include, for example, ADEPT (Antibody-Directed Enzyme Prodrug Therapy) and MDEPT (Melanocyte-Directed Enzyme Prodrug Therapy). The aim will be to provide drugs, increasingly, more specific, with greater effectiveness and fewer adverse effects. |
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| Autores principais: | Coelho, Rute Isabel Martins |
| Assunto: | Cancro Pró-fármacos de triazenos MDEPT Especificidade Eficácia Efeitos adversos Mestrado Integrado - 2014 |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Cancer has great impact on the contemporary society. It causes a dramatic decrease in the quality of life of all and also affects in the people around and every day deal with this scourge. Their causes can be diverse and are sometimes unknown; their mechanisms of resistance are difficult to overcome and the effectiveness of therapies that exist so far, is still not satisfactory. The development of antitumor agents is notorious, although the perfect drug for treat this disease has not yet been discovered. There are several classes of drugs with different mechanisms of action and different acting targets that can be used concurrently to stop all pathological pathways. Prodrugs of triazenes are a promising strategy in which different approaches include, for example, ADEPT (Antibody-Directed Enzyme Prodrug Therapy) and MDEPT (Melanocyte-Directed Enzyme Prodrug Therapy). The aim will be to provide drugs, increasingly, more specific, with greater effectiveness and fewer adverse effects. |
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