Publicação
Managing stress using trazodone - effects in hospitalized cats
| Resumo: | A prospective study was developed in this work with the aim to determine the effect of trazodone in reducing signs of stress in hospitalized cats (group 1; n=8), and to evaluate the safety and effect of trazodone administrated as an adjuvant anxiolytic drug to anesthetic premedication in cats undergoing elective surgery (group 2; n=6). Trazodone was orally administered to a total of eight cats selected for the group 1, at the dose of 50mg per cat. In the second study group, trazodone was orally administered to a total of six cats at the dose of 25mg per cat, one hour prior to sedation. Cats were observed and recorded for posterior evaluation of stress signs presented at different stages: immediately before administration (T0) and, every hour after the drug administration, for a total time period of 4 hours (T60, T120, T180, T240). In each observation, the level of stress of each cat was assessed through the identification of stress signs, using the Cat-Stress-Score (CSS), developed by M.R. Kessler and D.C. Turner (1997). The respiratory rate of the animals of both groups was also evaluated. Statistical analysis was performed with a generalized linear model (GLM) with logarithmic response distribution. Stress score was set as the dependent variable with independent factors Time (T0, T60, T120, T180, T240), Sex (Male and Female) and Admission (Surgery and Hospitalization) and their interactions. In addition, Dose was included in the model as a covariate (continuous variable). Multiple comparisons were Tukey-Kramer adjusted. The analysis was performed with the SAS OnDemand for Academics software ©. Results demonstrate that using a dose of 50 mg per animal, orally, trazodone may be a safe and effective method for reducing stress in hospitalized cats. Additionally, the 25 mg of trazodone used as an anxiolytic adjuvant to anesthetic premedication in cats undergoingsurgery, exhibited clinical effects 60 minutes after its administration. The drug’s duration of action was more visible at least 180 minutes. Although the results are promising, further studiesare needed, with larger sample sizes, to validate the safety and efficacy of the use of trazodonein the management of stress in this species. |
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| Autores principais: | Delgado, Cecília Veloso |
| Assunto: | Cats stress |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Trás-os-Montes e Alto Douro |
| Idioma: | inglês |
| Origem: | Repositório da UTAD |
| Resumo: | A prospective study was developed in this work with the aim to determine the effect of trazodone in reducing signs of stress in hospitalized cats (group 1; n=8), and to evaluate the safety and effect of trazodone administrated as an adjuvant anxiolytic drug to anesthetic premedication in cats undergoing elective surgery (group 2; n=6). Trazodone was orally administered to a total of eight cats selected for the group 1, at the dose of 50mg per cat. In the second study group, trazodone was orally administered to a total of six cats at the dose of 25mg per cat, one hour prior to sedation. Cats were observed and recorded for posterior evaluation of stress signs presented at different stages: immediately before administration (T0) and, every hour after the drug administration, for a total time period of 4 hours (T60, T120, T180, T240). In each observation, the level of stress of each cat was assessed through the identification of stress signs, using the Cat-Stress-Score (CSS), developed by M.R. Kessler and D.C. Turner (1997). The respiratory rate of the animals of both groups was also evaluated. Statistical analysis was performed with a generalized linear model (GLM) with logarithmic response distribution. Stress score was set as the dependent variable with independent factors Time (T0, T60, T120, T180, T240), Sex (Male and Female) and Admission (Surgery and Hospitalization) and their interactions. In addition, Dose was included in the model as a covariate (continuous variable). Multiple comparisons were Tukey-Kramer adjusted. The analysis was performed with the SAS OnDemand for Academics software ©. Results demonstrate that using a dose of 50 mg per animal, orally, trazodone may be a safe and effective method for reducing stress in hospitalized cats. Additionally, the 25 mg of trazodone used as an anxiolytic adjuvant to anesthetic premedication in cats undergoingsurgery, exhibited clinical effects 60 minutes after its administration. The drug’s duration of action was more visible at least 180 minutes. Although the results are promising, further studiesare needed, with larger sample sizes, to validate the safety and efficacy of the use of trazodonein the management of stress in this species. |
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