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Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

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Resumo:Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
Autores principais:Silva, João Carlos
Outros Autores:Ponte, Ana; Mota, Margarida; Pinho, Rolando; Vieira, Nuno; Oliveira, Rosa; Mota-Carvalho, Nelson; Gomes, Ana Catarina; Afecto, Edgar; Carvalho, João
Assunto:Fecal microbiota transplantation Carbapenamase-producing enterobacteriaceae Multidrug-resistant infections Decolonization Intestinal carriage
Ano:2020
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade Católica Portuguesa
Idioma:inglês
Origem:Veritati - Repositório Institucional da Universidade Católica Portuguesa

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