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Electroencephalogram hybrid method for alzheimer early detection

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Resumo:Alzheimer’s disease (AD) is a neurocognitive illness that leads to dementia and mainly affects the elderly. As the percentage of old people is strongly increasing worldwide, it is urgent to develop contributions to solve this complex problem. The early diagnosis at AD first stage known as Mild Cognitive Impairment (MCI) needs a better accuracy and there is not a biomarker able to detect AD without invasive tests. In this study, Electroencephalogram (EEG) signals have been used to serve as a way of finding parameters to improve AD diagnosis in first stages. For that, a hybrid method based on a Cepstral analysis of EEG Discrete Wavelet Transform (DWT) multiband decomposition was developed. Several Cepstral Distances (CD) were extracted to verify the lag between cepstra of conventional bands signals. The results showed that this hybrid method is a good tool for describing and distinguishing the AD EEG activity along its different stages because several statistically significant parameters variations were found between controls, MCI, moderate AD and advanced AD (the lowest p-value=0.003<0.05).
Autores principais:Rodrigues, Pedro Miguel
Outros Autores:Freitas, Diamantino; Teixeira, João Paulo; Bispod, Bruno; Alves, Dílio; Garrett, Carolina
Assunto:Alzheimer’s diasease Early diagnosis Cepstral analisys Wavelet transform Electroencephalogram signals Cepstral distances
Ano:2018
País:Portugal
Tipo de documento:documento de conferência
Tipo de acesso:acesso aberto
Instituição associada:Universidade Católica Portuguesa
Idioma:inglês
Origem:Veritati - Repositório Institucional da Universidade Católica Portuguesa
Descrição
Resumo:Alzheimer’s disease (AD) is a neurocognitive illness that leads to dementia and mainly affects the elderly. As the percentage of old people is strongly increasing worldwide, it is urgent to develop contributions to solve this complex problem. The early diagnosis at AD first stage known as Mild Cognitive Impairment (MCI) needs a better accuracy and there is not a biomarker able to detect AD without invasive tests. In this study, Electroencephalogram (EEG) signals have been used to serve as a way of finding parameters to improve AD diagnosis in first stages. For that, a hybrid method based on a Cepstral analysis of EEG Discrete Wavelet Transform (DWT) multiband decomposition was developed. Several Cepstral Distances (CD) were extracted to verify the lag between cepstra of conventional bands signals. The results showed that this hybrid method is a good tool for describing and distinguishing the AD EEG activity along its different stages because several statistically significant parameters variations were found between controls, MCI, moderate AD and advanced AD (the lowest p-value=0.003<0.05).