Author(s): Vieira, Raquel ; Souto, Selma B. ; Sánchez-López, Elena ; Machado, Ana López ; Severino, Patrícia ; Jose, Sajan ; Santini, Antonello ; Fortuna, Ana ; García, Maria Luisa ; Souto, Eliana B.
Date: 2019
Persistent ID: https://hdl.handle.net/10316/107084
Origin: Estudo Geral - Universidade de Coimbra
Subject(s): diabetes mellitus; animal models; in vivo; administration routes
Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic β-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.
Institute of Nanoscience and Nanotechnology under the project ART (2018) and M-ERA-NET/0004/2015-PAIRED.
