Author(s): Favaro-Trindade, Carmen S. ; Matos Junior, Fernando E. de ; Okuro, Paula K. ; Dias-Ferreira, João ; Cano, Amanda ; Severino, Patricia ; Zielińska, Aleksandra ; Souto, Eliana
Date: 2021
Persistent ID: https://hdl.handle.net/10316/95602
Origin: Estudo Geral - Universidade de Coimbra
Subject(s): Spray chilling; Congealing spray; Spray cooling; Lipid nanoparticles; Oral drug delivery
Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.
This work was also supported by the National Science Centre within the MINIATURA 4 for a single research activity carried out by Aleksandra Zieli ´nska (grant no: 2020/04/X/ST5/00789), and by the Institute of Human Genetics, Polish Academy of Sciences by the internal grant for the implementation of a single scientific activity.
