Author(s): Silva, Daniela Rosendo ; Aguiar, Gonçalo ; Luís, Carla ; Soares, Raquel ; Coelho, Pedro ; Coelho, Pedro
Date: 2024
Persistent ID: http://hdl.handle.net/10400.22/30611
Origin: Repositório Científico do Instituto Politécnico do Porto
Subject(s): Adipose tissue; Vascular dysfunction; Type 2 diabetes; Cancer
The overgrowth of adipose tissue is a major trigger for the development of other metabolic disorders, like insulin resistance, hypertension, type 2 diabetes, cardiovascular disease, and cancer. Among the causes of this association lies the fact that increased adiposity is accompanied by a nonfunctioning vascular component. Accordingly, vascular dysfunction within the adipose tissue is common in obesity and associated with deregulated metabolic cues such as decreased nitric oxide (NO), increased oxidative stress and hypoxia. These will result in metabolic comorbidities, which ultimately may end up in type 2 diabetes and cancer. The current study addresses the state-of-the-art regarding the mechanisms involved, focusing on two diseases with huge prevalence worldwide: type 2 diabetes and cancer. Understanding how adipose tissue vascular dysfunction impacts on metabolic disease is of paramount importance and may lead to innovative therapeutic approaches.
