Autor(es):
Leventakou, V ; Roumeliotaki, T ; Martinez, D ; Barros, H ; Brantsaeter, AL ; Casas, M ; Charles, MA ; Cordier, S ; Eggesbo, M ; van Eijsden, M ; Forastiere, F ; Gehring, U ; Govarts, E ; Halldorsson, TI ; Hanke, W ; Haugen, M ; Heppe, D ; Heude, B ; Inskip, HM ; Jaddoe, V ; Jansen, M ; Kelleher, C ; Meltzer, HM ; Merletii, F ; Moltó-Puigmartí, C ; Mommers, M ; Murcia, M ; Oliveira, A ; Olsen, SF ; Pele, F ; Polanska, K ; Porta, D ; Richiardi, L ; Robinson, SM ; Stigum, H|Strøm, M ; Sunyer, J ; Thijs, C ; Viljoen, K ; Vrijkotte, T ; Wijga, AH ; Kogevinas, M ; Vrijheid, M ; Chatzi, L
Data: 2014
Identificador Persistente: http://hdl.handle.net/10216/114866
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): Fish intake; Pregnancy; Fetal growth
Descrição
BACKGROUND: Fish is a rich source of essential nutrients for fetal development, but in contrast, it is also a well-known route of exposure to environmental pollutants. OBJECTIVE: We assessed whether fish intake during pregnancy is associated with fetal growth and the length of gestation in a panel of European birth cohort studies. DESIGN: The study sample of 151,880 mother-child pairs was derived from 19 population-based European birth cohort studies. Individual data from cohorts were pooled and harmonized. Adjusted cohort-specific effect estimates were combined by using a random- and fixed-effects meta-analysis. RESULTS: Women who ate fish >1 time/wk during pregnancy had lower risk of preterm birth than did women who rarely ate fish (≤ 1 time/wk); the adjusted RR of fish intake >1 but <3 times/wk was 0.87 (95% CI: 0.82, 0.92), and for intake ≥ 3 times/wk, the adjusted RR was 0.89 (95% CI: 0.84, 0.96). Women with a higher intake of fish during pregnancy gave birth to neonates with a higher birth weight by 8.9 g (95% CI: 3.3, 14.6 g) for >1 but <3 times/wk and 15.2 g (95% CI: 8.9, 21.5 g) for ≥ 3 times/wk independent of gestational age. The association was greater in smokers and in overweight or obese women. Findings were consistent across cohorts. CONCLUSION: This large, international study indicates that moderate fish intake during pregnancy is associated with lower risk of preterm birth and a small but significant increase in birth weight.
