Autor(es): Fragão-Marques, M ; Barroso, I ; Farinha, R ; Miranda, IM ; Martins, D ; Mancio, J ; Rocha-Neves, J ; Guimarães, JT ; Leite-Moreira, A ; Falcão-Pires, I
Data: 2021
Identificador Persistente: https://hdl.handle.net/10216/149592
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): atrial fibrillation; aortic stenosis; cardiac surgery; pericardial fluid; biomarker; GDF-15; NT-pro-BNP
Aims: This study aimed to evaluate the association of GDF-15 and NT-pro-BNP in two different biological matrices with AF in severe aortic stenosis patients undergoing aortic valve replacement surgery (AVR), its association with atrial matrix remodeling, as well as with 30-day postoperative outcomes. Main Methods: One hundred and twenty-six patients between 2009 and 2019 with severe aortic stenosis undergoing AVR surgery in a tertiary hospital were assessed. Key Findings: pericardial fluid GDF-15 and pericardial fluid and serum NT-pro-BNP were increased in AF patients with aortic stenosis. COL1A1 and COL3A1 gene expression increased when pericardial fluid NT-pro-BNP values were higher. TIMP4 was positively correlated with pericardial fluid GDF-15. Significance: GDF-15 and NT-pro-BNP in the pericardial fluid are biomarkers of atrial fibrillation in aortic stenosis and correlate with atrial matrix remodeling. AKI is predicted by both serum and pericardial fluid GDF-15.
