Author(s):
Amaral, R ; Jácome, C ; Almeida, R ; Pereira, AM ; Alves-Correia, M ; Mendes, S ; Rodrigues, JC ; Carvalho, J ; Araújo, L ; Costa, A ; Silva, A ; Teixeira, MF ; Ferreira-Magalhães, M ; Alves, RR ; Moreira, AS ; Fernandes, RM ; Ferreira, R ; Leiria-Pinto, P ; Neuparth, N ; Bordalo, D ; Todo Bom, A ; Cálix, MJ ; Ferreira, T ; Gomes, J ; Vidal, C ; Mendes, A ; Vasconcelos, MJ ; Silva, PM ; Ferraz, J ; Morête, A ; Pinto, CS ; Santos, N ; Loureiro, CC ; Arrobas, A ; Marques, ML ; Lozoya, C ; Lopes, C ; Cardia, F ; Loureiro, CC ; Câmara, R ; Vieira, I ; Silva, S ; Silva, E ; Rodrigues, N ; Fonseca, JA
Date: 2021
Persistent ID: http://hdl.handle.net/10400.17/3752
Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
Subject(s): Adolescent; Female; Humans; Male; Phenotype; Portugal; Prospective Studies; Spain; Asthma; HDE ALER
Description
We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
