Autor(es): Rosadas, Marta ; Sousa, Teresa ; Sousa, Alda ; Ribeiro, Viviana P. ; Oliveira, Ana L.
Data: 2025
Identificador Persistente: http://hdl.handle.net/10400.14/55470
Origem: Veritati - Repositório Institucional da Universidade Católica Portuguesa
Assunto(s): Biocompatibility; Biological material; in vitro tests; Leachables; Skin; Wound healing
Burn wounds remain a significant challenge in medical care, requiring effective wound coverage to restore the skin barrier and promote healing or support skin reconstruction. The use of autologous grafts as substitutes is still the standard treatment, however, it is not suitable for deep and extensive burns (1). Decellularized skin allografts and xenografts have emerged as suitable options, using decellularization to remove the immunogenic material present in the tissue while preserving the ECM components and interesting biomolecules (3). Considering that xenografts source availability is significantly higher and free of ethical concerns, this study describes for the first time a protocol for decellularizing rabbit dermis, leveraging a valuable agro-food by-product which exceeds 5000 skins/day at the world-leading company Cortadoria Nacional de Pêlo, and studies its potential for skin regeneration.
