Is decellularized rabbit dermis a viable option for skin wound healing and regeneration?

• Author(s): Rosadas, Marta ; Sousa, Teresa ; Sousa, Alda ; Ribeiro, Viviana P. ; Oliveira, Ana L.
• Date: 2025
• Persistent ID: http://hdl.handle.net/10400.14/55471
• Origin: Veritati - Repositório Institucional da Universidade Católica Portuguesa
• Document Type: Conference poster not in proceedings
• Language: English
• Contributor(s): Veritati

Description

Burn wounds remain a major clinical challenge, requiring effective coverage to restore the skin barrier and support healing. Autologous grafts are the standard treatment but are limited in deep or extensive burns [1]. Decellularized allografts and xenografts offer alternatives by removing immunogenic material while preserving ECM components [2]. Considering that xenografts source availability is significantly higher and free of ethical concerns, this study describes for the first time a protocol for decellularizing rabbit dermis, leveraging a valuable agro-food by-product that exceeds 5000 skins/day at the world-leading company Cortadoria Nacional de Pêlo, and studies its potential for skin regeneration.