Autor(es): Micheletti, Ana Camila ; Honda, Neli Kika ; Lima, Dênis Pires de ; Beatriz, Adilson ; Sant'ana, Maria Rita ; Carvalho, Nádia Cristina Pereira ; Matos, Maria de Fatima Cepa ; Queiróz, Lyara Meira Marinho ; Bogo, Danielle ; Zorzatto, José Roberto
Data: 2011
Origem: Oasisbr
Assunto(s): Xantonas; Staphylococcus Aureus; Linhagem Celular Tumoral; Xanthones; Cell Line, Tumor
A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.
