Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta 1-induced apoptosis in rat hepatocytes

• Author(s): Sola, S ; Amaral, J ; Castro, RE ; Ramalho, RM ; Borralho, PM ; Kren, BT ; Tanaka, H ; Steer, CJ ; Rodrigues, CMP
• Date: 2005
• Persistent ID: http://hdl.handle.net/10451/21504
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Gastroenterology & Hepatology
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico de Acesso Aberto da ULisboa

Description

Ursodeoxycholic acid (UDCA) inhibits classical mitochondrial pathways of apoptosis by either directly stabiliz* mitochondrial membranes or modulating specific upstream targets. Furthermore, UDCA regulates apoptosis-related genes from transforming growth f