Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours

• Author(s): Torres de Oliveira, Antonio Talvane ; Reis, Rui M. ; Afonso, Julieta ; Martinho, Olga ; Matos, Delcio ; Carvalho, Andre Lopes ; Vazquez, Vinicius Lima ; Silva, Thiago Buosi ; Scapulatempo, Cristovam ; Saad, Sarhan Sydney ; Longatto-Filho, Adhemar
• Date: 2020
• Persistent ID: http://hdl.handle.net/11449/194730
• Origin: Oasisbr
• Subject(s): Gastrointestinal stromal tumours; KIT; D2-40; VEGF-C; VEGFR-3
• Document Type: Journal article
• Language: English

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Portuguese Science and Technology Foundation

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density BDV - assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST's cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD.

Barretos Canc Hosp, Pio XII Fdn, Dept Digest Surg, Sao Paulo, Brazil

Barretos Canc Hosp, Pio XII Fdn, Dept Pathol, Sao Paulo, Brazil

Barretos Canc Hosp, Pio XII Fdn, Ctr Researcher Support, Sao Paulo, Brazil

Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal

Barretos Canc Hosp, Pio XII Fdn, Mol Oncol Res Ctr, Sao Paulo, Brazil

Alto Ave Super Inst Hlth ISAVE, Povoa De Lanhoso, Portugal

Fed Univ Sao Paulo UNIFESP, Sch Med, Dept Gastroenterol, Sao Paulo, Brazil

Univ Sao Paulo, Sch Med, Lab Med Invest LIM 14, Dept Pathol, BR-05508 Sao Paulo, Brazil

Portuguese Science and Technology Foundation: SFRH/BD/36463/2007

CNPq: 476936/2008-0