Author(s):
Sonon, Paulin ; Tokplonou, Léonidas ; Sadissou, Ibrahim ; M'po, Kuumaaté K.G. ; Glitho, Sonya S.C. ; Agniwo, Privat ; Ibikounlé, Moudachirou ; Souza, Andréia S. [UNESP] ; Massaro, Juliana Doblas ; Gonzalez, Daniel ; Tchégninougbo, Théophile ; Ayitchédji, Aurèle ; Massougbodji, Achille ; Moreau, Philippe ; Garcia, André ; Milet, Jacqueline ; Sabbagh, Audrey ; Mendes-Junior, Celso T. ; Moutairou, Kabirou A. ; Castelli, Erick C. [UNESP] ; Courtin, David ; Donadi, Eduardo A.
Date: 2021
Persistent ID: http://hdl.handle.net/11449/207927
Origin: Oasisbr
Subject(s): Antibody; Haplotype; HLA-Ib; Plasmodium falciparum; SNV
Description
Made available in DSpace on 2021-06-25T11:03:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-01
Institut de Recherche pour le Développement
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Background: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/−G genes in malaria. We evaluated the entire HLA-E/-F/−G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/−G genes were genotyped using massively parallel sequencing. Anti P.f. antibodies were evaluated using ELISA. Results: Children carrying the G allele at HLA-F (−1499,rs183540921) showed increased P.f. asymptomatic/symptomatic ratio, suggesting that these children experienced more asymptomatic P.f. episodes than symptomatic one. Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared to the non-carriers. No associations were observed for the HLA-E gene. Conclusion: HLA-F associations may be related to the differential expression profiles of the encoded immunomodulatory molecules, and the regulatory sites at the HLA-G 3'UTR may be associated to posttranscriptional regulation of HLA-G and to host humoral response against P.f.
Post-graduate Program in Basic and Applied Immunology Ribeirão Preto Medical School University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre
Immunogenetic Laboratory Immunology Department Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
Centre d'Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE) faculté des Sciences de la Santé Cotonou
Université de Paris, UMR 261 MERIT, IRD
Département de Zoologie faculté des Sciences et Techniques Université d'Abomey-Calavi
Intertryp IRD Cirad University of Montpellier, Avenue Agropolis
São Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory, Av. Prof. Dr. Walter Maurício Correa, s/n
Centre Médical Saint Joseph Sô Ava
CEA DRF-Institut François Jacob Service de Recherches en Hémato-Immunologie, Hopital Saint-Louis
Université de Paris CEA U976 HIPI Unit (Human Immunology Physiopathology Immunotherapy) Institut de Recherche Saint-Louis
Departamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo, AV Bandeirantes, 3900
Laboratoire de Biologie et Physiologie Cellulaire Université d'Abomey-Calavi
São Paulo State University (UNESP) Department of Pathology School of Medicine
São Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory, Av. Prof. Dr. Walter Maurício Correa, s/n
São Paulo State University (UNESP) Department of Pathology School of Medicine
CAPES: #304931/2014-1
CAPES: #466036/2013-5
CAPES: 302060/2019-07
CAPES: 406594/2013-9
CNPq: PROCAD#88881-068436/2014-1
