Author(s):
Ganassin, Rayane ; Da Silva, Victor Carlos Mello ; Araujo, Victor Hugo Sousa ; Tavares, Giulia Rosa ; Da Silva, Patrícia Bento ; Cáceres-Vélez, Paolin Rocio ; Porcel, Joaquin E Martínez ; Rodrigues, Mosar Corrêa ; Andreozzi, Patrizia ; Fernandes, Richard Perosa [UNESP] ; Fonseca-Santos, Bruno ; Moya, Sergio ; Azevedo, Ricardo Bentes ; Chorilli, Marlus [UNESP] ; Muehlmann, Luis Alexandre
Date: 2022
Persistent ID: http://hdl.handle.net/11449/234097
Origin: Oasisbr
Subject(s): cancer; colloid; colon adenocarcinoma; drug delivery; murumuru butter
Description
Made available in DSpace on 2022-05-01T13:41:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.
Laboratory of Nanoscience and Immunology Faculty of Ceilandia University of Brasilia, DF
Department of Genetics and Morphology Institute of Biological Sciences University of Brasilia
Soft Matter Laboratory Center for Cooperative Research in Biomaterials (CIC BiomaGUNE)
School of Biosciences The University of Melbourne
Laboratory of Thermal Analysis Ivo Giolitto Chemical Institute São Paulo State University São Paulo, SP
University of Campinas (UNICAMP), São Paulo
School of Pharmaceutical Sciences São Paulo State University (UNESP)
Laboratory of Thermal Analysis Ivo Giolitto Chemical Institute São Paulo State University São Paulo, SP
School of Pharmaceutical Sciences São Paulo State University (UNESP)
