Gene expression of peripheral blood lymphocytes may discriminate patients with schizophrenia from controls

• Author(s): Palha, Joana Almeida ; Maschietto, Mariana ; Silva, Aderbal R. ; Puga, Renato ; Lima, Leandro ; Pereira, Carlos B. ; Nakano, Eduardo Y. ; Mello, Barbara ; Gama, Clarissa ; Belmonte-de-Abreu, Paulo ; Carraro, Dirce M. ; Brentani, Helena
• Date: 2012
• Persistent ID: https://hdl.handle.net/1822/33617
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Schizophrenia; Peripheral molecular marker; Drugs
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

To identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral blood as biological material for diagnosis in schizophrenia.