Fluconazole versus Voriconazole: Candida glabrata biofilms response to different azoles

• Author(s): Rodrigues, Célia Fortuna ; Gonçalves, Bruna ; Rodrigues, E. ; Silva, Sónia Carina ; Azeredo, Joana ; Henriques, Mariana
• Date: 2015
• Persistent ID: https://hdl.handle.net/1822/37877
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Candida glabrata; Biofilms; Resistance mechanisms; Antifungals; Matrix
• Document Type: Other
• Language: English
• Contributor(s): Universidade do Minho

Description

Candida glabrata is the second most prevalent yeast in fungal infections, especially in immunocompromised and/or hospitalized patients. The azole resistance within this species is very well-known and results in a low therapeutic response of C. glabrata infections, particularly when associated with biofilms. Objective - To understand the different efficacies of two azoles against C. glabrata biofilms: - fluconazole (Flu), a long time used drug - voriconazole (Vcz), a latest drug used only in hospitals.