Fluconazole versus Voriconazole: Candida glabrata biofilms response to different azoles

• Autor(es): Rodrigues, Célia Fortuna ; Gonçalves, Bruna ; Rodrigues, E. ; Silva, Sónia Carina ; Azeredo, Joana ; Henriques, Mariana
• Data: 2015
• Identificador Persistente: https://hdl.handle.net/1822/37877
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Candida glabrata; Biofilms; Resistance mechanisms; Antifungals; Matrix
• Tipo de Documento: Outro
• Idioma: Inglês
• Contribuidor(es): Universidade do Minho

Descrição

Candida glabrata is the second most prevalent yeast in fungal infections, especially in immunocompromised and/or hospitalized patients. The azole resistance within this species is very well-known and results in a low therapeutic response of C. glabrata infections, particularly when associated with biofilms. Objective - To understand the different efficacies of two azoles against C. glabrata biofilms: - fluconazole (Flu), a long time used drug - voriconazole (Vcz), a latest drug used only in hospitals.