Author(s): Pereira, Daniela S. M. ; Rodrigues, Ana Rita Oliveira ; Almeida, B. G. ; Araújo, João P. ; Machado, V. A. ; Queiroz, Maria João R. P. ; Coutinho, Paulo J. G. ; Castanheira, Elisabete M. S.
Date: 2017
Persistent ID: https://hdl.handle.net/1822/46116
Origin: RepositóriUM - Universidade do Minho
Subject(s): Magnetic nanoparticles; Drug delivery; Magnetoliposomes; New antitumor drugs
In this work, calcium ferrite nanoparticles were prepared and characterized. The structural and magnetic properties of the nanoparticles were evaluated by XRD, TEM and SQUID. The synthesized nanoparticles were either entrapped in liposomes, originating aqueous magnetoliposomes (AMLs), or covered with a lipid bilayer, forming solid magnetoliposomes (SMLs). Magnetoliposomes present average diameters around 150 nm, suitable for biomedical applications. The magnetoliposomes were loaded with new potential anticancer drugs, thienopyridine derivatives, with a strong antitumor activity against breast cancer cells.
