Author(s): Rodrigues, Ana Rita Oliveira ; Silva, Pedro M. L. ; Almeida, B. G. ; Araújo, João P. ; Queiroz, Maria João R. P. ; Castanheira, Elisabete M. S. ; Coutinho, Paulo J. G.
Date: 2017
Persistent ID: https://hdl.handle.net/1822/46126
Origin: RepositóriUM - Universidade do Minho
Subject(s): Magnetic nanoparticles; Drug delivery; Magnetoliposomes; New antitumor compounds
In this work, iron oxide nanoparticles (NPs), with diameters around 12 nm, were synthesized by coprecipitation method. Both aqueous and solid magnetic liposomes containing magnetite NPs were obtained, with sizes below 140 nm. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being located mainly in the lipid membrane. A promising application of these magnetic liposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.
