Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma

• Author(s): Afonso, Julieta Alexandra Pereira ; Pinto, Tatiana ; Sousa, Susana Patrícia Simões ; Schmitt, Fernando ; Longatto, Adhemar ; Pinheiro, Céline ; Marques, Herlander ; Baltazar, Fátima
• Date: 2019
• Persistent ID: https://hdl.handle.net/1822/62454
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Non-Hodgkin lymphoma; Diffuse large B cell lymphoma; Warburg effect; Monocarboxylate transporters; Metabolic symbiosis; AZD3965
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition.