Author(s):
Gaifem, Joana ; Mendes-Frias, Ana ; Wolter, Mathis ; Steimle, Alex ; Garzón, Maria Jose ; Ubeda, Carles ; Nobre, Clarisse ; González, Abigail ; Pinho, Salomé S. ; Cunha, Cristina Amorim ; Carvalho, Agostinho ; Castro, António Gil ; Desai, Mahesh S. ; Rodrigues, Fernando José dos Santos ; Silvestre, Ricardo Jorge Leal
Date: 2024
Persistent ID: https://hdl.handle.net/1822/91610
Origin: RepositóriUM - Universidade do Minho
Subject(s): Akkermansia muciniphila; Parabacteroides distasonis; Colitis; Microbiome; ILC; Gut immunity
Description
The contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. Nevertheless, the etiology of inflammatory bowel disease, which is known to be influenced by genetics, immune response, and environmental cues, remains unclear. Unlocking novel players involved in the dictation of a protective gut, namely, in the microbiota component, is therefore crucial to develop novel strategies to tackle IBD. Herein, we revealed a synergistic interaction between two commensal bacterial strains, Akkermansia muciniphila and Parabacteroides distasonis, which induce protection against both acute and chronic models of colitis induction, by enhancing epithelial barrier integrity and promoting group 3 innate lymphoid cells in the colonic mucosa. This study provides a novel insight on how commensal bacteria can beneficially act to promote intestinal homeostasis, which may open new avenues toward the use of microbiome-derived strategies to tackle IBD.
