Influence of P53 on the radiotherapy response of hepatocellular carcinoma

• Author(s): Gomes, AR ; Abrantes, AM ; Brito, AF ; Laranjo, M ; Casalta-Lopes, JE ; Gonçalves, AC ; Sarmento-Ribeiro, AB ; Botelho, MF ; Tralhão, JG
• Date: 2015
• Persistent ID: http://hdl.handle.net/10400.4/1898
• Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
• Subject(s): Carcinoma Hepatocelular; Proteína Supressora de Tumor p53
• Document Type: Journal article
• Language: English
• Contributor(s): RIHUC

Description

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it has a poor prognosis and few therapeutic options. Radiotherapy is one of the most effective forms of cancer treatment, and P53 protein is one of the key molecules determining how a cell responds to radiotherapy. The aim of this study was to determine the therapeutic efficacy of iodine-131 in three human HCC cell lines.