Author(s):
Silva, Ana Teresa ; Oliveira, Isabel S. ; Gomes, Joana ; Aguiar, Luísa ; Fontinha, Diana ; Duarte, Denise ; Nogueira, Fátima ; Prudêncio, Miguel ; Marques, Eduardo F. ; Teixeira, Cátia ; Ferraz, Ricardo ; Gomes, Paula
Date: 2022
Persistent ID: http://hdl.handle.net/10362/149142
Origin: Repositório Institucional da UNL
Subject(s): Antimalarial; blood-stage; fatty acid; ionic liquid; liver-stage; Plasmodium; SAIL; surface activity; Biochemistry; Molecular Medicine; Pharmacology; Drug Discovery; Pharmacology, Toxicology and Pharmaceutics(all); Organic Chemistry; Pharmacology (medical); SDG 3 - Good Health and Well-being; SDG 9 - Industry, Innovation, and Infrastructure; SDG 12 - Responsible Consumption and Production
Description
Funding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH
Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.
