Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

• Author(s): Isidro, Joana ; Santos, Andrea ; Nunes, Alexandra ; Borges, Vitor ; Silva, Catarina ; Vieira, Luis ; Mendes, Aristides L. ; Serrano, Monica ; Henriques, Adriano O. ; Gomes, Joao Paulo ; Oleastro, Monica
• Date: 2018
• Origin: Repositório Institucional da UNL
• Document Type: Journal article
• Language: English
• Contributor(s): Instituto de Tecnologia Química e Biológica António Xavier (ITQB); RUN

Description

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.