Author(s): Higuchi,Celio Takashi ; Pavan,Fernando Rogério ; Leite,Clarice Queico Fujimura ; Sannomiya,Miriam ; Vilegas,Wagner ; Leite,Sergio Roberto de Andrade ; Sacramento,Luis Vitor S. ; Sato,Daisy Nakamura
Date: 2008
Origin: Oasisbr
Subject(s): Byrsonima crassa; antitubercular activity; triterpenes
We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.
