Author(s): Moreira,Raquel R. D. ; Martins,Gilmarcio Z. ; Pietro,Rosemeire C. L. R. ; Sato,Daisy N. ; Pavan,Fernando R. ; Leite,Sergio R.A. ; Vilegas,Wagner ; Leite,Clarice Q. F.
Date: 2013
Origin: Oasisbr
Subject(s): flavonoids; Mycobacterium; naphthopyranone; Paepalanthus spp
Paepalanthus spp., Eriocaulaceae, are native plants from Brazil known as "sempre-vivas" (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4'-O-β-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The MIC value of 500 µg/mL was verified for all compounds tested against M. tuberculosis H37Rv. For M. avium, the MIC value ranged from 1000-2000 µg/mL excepting to naphthopyranone fractions with MIC of 500 µg/mL. This is the first report of activity determination of Paepalanthus spp. flavonoids activity against Mycobacterium tuberculosis and M. avium.
