Author(s):
Carvalho, Karine Maria Martins Bezerra ; MarinhoFilho, José Delano Barreto ; Melo, Tiago Sousa de ; Araújo, Ana Jérsia ; Quetz, Josiane da Silva ; Cunha, Mariado Perpétuo Socorro Saldanha da ; Melo, Karina Moura de ; Silva, Armenio Andrede Carvalho Almeida da ; Tomé, Adriana Rocha ; Havt, Alexandre ; Fonseca, Said Gonçalves da Cruz ; Brito, Gerly Annede Castro ; Chaves, Mariana Helena ; Rao, Vietla Satyanarayana ; Santos, Flávia Almeida
Date: 2016
Origin: Oasisbr
Subject(s): Dieta; Obesidade
Description
Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolicdisorders.ThepresentstudyinvestigatedtheantiobesitypropertiesofresinfromProtiumheptaphyllum(RPH)andthe possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, netenergyintake,abdominalfataccumulation,plasmaglucose,amylase,lipase,triglycerides,andtotalcholesterolrelativetotheir respectivecontrols,whichwereRPHunfed.Additionally,RPHtreatment,whilesignificantlyelevatingtheplasmalevelofghrelin hormone,decreasedthelevelsofinsulin,leptin,andresistin.Besides,HFD-inducedincreasesinplasmalevelsofproinflammatory mediators TNF-, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore, in vitro studies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50g/mL.ThesefindingssuggestthattheantiobesepotentialofRPHislargelyduetoitsmodulatoryeffectsonvarioushormonal andenzymaticsecretionsrelatedtofatandcarbohydratemetabolismandtotheregulationofobesity-associatedinflammation.
