Autor(es): Slyepchenko, Anastasiya ; Maes, Michael ; Jacka, Felice N. ; Köhler, Cristiano A. ; Barichello, Tatiana ; McIntyre, Roger S. ; Berk, Michael ; Grande, Iria ; Foster, Jane A. ; Vieta, Eduard ; Carvalho, André F.
Data: 2017
Origem: Oasisbr
Assunto(s): Obesidade; Depressão; Síndrome de Fadiga Crônica; Fatigue Syndrome, Chronic
Background: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hy- pothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and re-sultant bacterial translocation add a new element to the bi- directional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed/MEDLINE data- base up until May 1, 2016 for studies which investigated in- testinal dysbiosis and bacterial translocation (the ‘leaky gut’) in the pathophysiology of MDD and co-occurring somatic
