Autor(es):
Collatuzzo, G ; Negri, E ; Pelucchi, C ; Bonzi, R ; Turati, F ; Rabkin, CS ; Liao, LM ; Sinha, R ; Palli, D ; Ferraroni, M ; López-Carrillo, L ; Lunet, N ; Morais, S ; Albanes, D ; Weinstein, SJ ; Parisi, D ; Zaridze, D ; Maximovitch, D ; Dierssen-Sotos, T ; Jiménez-Moleón, JJ ; Vioque, J ; de la Hera, MG ; Curado, MP ; Dias-Neto, E ; Hernández-Ramírez, RU ; López-Cervantes, M ; Ward, MH ; Tsugane, S ; Hidaka, A ; Lagiou, A ; Lagiou, P ; Zhang, ZF ; Trichopoulou, A ; Karakatsani, A ; Camargo, MC ; La Vecchia, C ; Boffetta, P
Data: 2023
Identificador Persistente: https://hdl.handle.net/10216/154264
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): gastric cancer; diet; nutrition; yoghurt
Descrição
Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
