Author(s): Micheletti, Ana Carolina ; Beatriz, Adilson ; Lima, Dênis Pires de ; Honda, Neli Kika ; Pessoa, Cláudia do Ó ; Moraes, Manoel Odorico de ; Lotufo, Letícia Veras ; Magalhães, Hemerson Iury Ferreira ; Carvalho, Nádia Cristina Pereira
Date: 2011
Origin: Oasisbr
Subject(s): Líquens; Xantonas; Química; Lichens; Xanthones; Chemistry
From the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were obtained norlichexanthone, 3-O-methylnorlichexanthone, 3-O-methyl-6-O-prenylnorlichexanthone, 3,6-di-O-prenyl-norlichexanthone, 3,6-bis[(3,3-dimethyloxyran-2-il)methoxy]-1-hydroxy-8-methyl-9H-xanten-9-one and 3,6-bis[3-(dimethylamine)propoxy]-1-hydroxy-8-methyl-9H-xanten-9-one. The last compound was the most active against S. aureus.
