Author(s): Lima, Dênis Pires de ; Beatriz, Adilson ; Ramos, Alexandre Ayoroa ; Siqueira, João Máximo de ; Oliveira, Celso Corrêa de ; Marques, Maria Rita
Date: 2011
Origin: Oasisbr
Subject(s): Sesquiterpenos; Células Tumorais Cultivadas; Avaliação de Medicamentos; Plantas Medicinais; Sesquiterpenes; Tumor Cells, Cultured; Drug Evaluation; Plants, Medicinal
The sesquiterpene (+)-allo-aromadendrane-10β-14-diol 1 was the lead compound to the preparation of several derivatives in order to test their biological activity against A. salina, C. sphaerospermum, E. coli and S. aureus. In this way the monoalcohols (+)-viridiflorol 4, 9 and 11 were synthesized from 1 together with the acetal 6, the ketal 7, and the ketone 8. The oxirane 3 and nitrile 5 were also prepared using as an intermediate the tosylate derivative 2.
