Camelized rabbit-derived VH single-domain Intrabodies Against vif strongly neutralize HIV-1 infectivity

• Author(s): da Silva, FA ; Santa-Marta, M ; Freitas-Vieira, A ; Mascarenhas, P ; Barahona, I ; Moniz-Pereira, J ; Gabuzda, D ; Goncalves, J
• Date: 2004
• Persistent ID: http://hdl.handle.net/10451/21600
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Biochemistry & Molecular Biology
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico de Acesso Aberto da ULisboa

Description

We recently developed a specific single-chain antibody from immunized rabbits to HIV-1 Vif protein that was expressed intracellularly and inhibited reverse transcription and viral replication. The Vif of HIV-1 overcomes the innate antiviral activity of a