Author(s):
Rodrigues, Ana Rita Oliveira ; Mendes, Pedro M. F. ; Silva, Pedro M. L. ; Machado, Vera Alexandra Pereira ; Almeida, B. G. ; Araújo, João P. ; Queiroz, Maria João R. P. ; Castanheira, Elisabete M. S. ; Coutinho, Paulo J. G.
Date: 2017
Persistent ID: https://hdl.handle.net/1822/46278
Origin: RepositóriUM - Universidade do Minho
Subject(s): Magnetic nanoparticles; Drug delivery; Magnetoliposomes; New antitumor compounds; Iron oxide nanoparticles; Aqueous magnetoliposomes; Solid magnetoliposomes; Antitumor drug; Dual cancer therapy
Description
Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.
