Author(s): Andrade, Raquel G. D. ; Santos-Pereira, Cátia ; Ferreira, Débora Carina Gonçalves Abreu ; Castanheira, Elisabete M. S. ; Rodrigues, L. R. ; Figueira, Alexander Carneiro ; Mayán Santos, María D.
Date: 2024
Persistent ID: https://hdl.handle.net/1822/95071
Origin: RepositóriUM - Universidade do Minho
Subject(s): Breast cancer; Magnetoliposomes; Photothermal therapy; Lactoferrin
Nanoparticle-based drug delivery systems can afford an alternative treatment for breast cancer, overcoming conventional therapy’s limitations. In particular, superparamagnetic iron oxide nanoparticles entrapped in liposomes have gained significant interest in the biomedical field due to their exceptional properties, like enabling their accumulation at the intended target site when exposed to an external magnetic field and facilitate the generation of heat under an external stimulus such as magnetic field [1] and near-infrared radiation, commonly referred to as magnetic hyperthermia and photothermal therapy, respectively. These magnetic liposomes have the ability to encapsulate therapeutic agents, including lactoferrin [2], a well-known protein for its anticancer properties and specificity for breast cancer cells [3]. The combination of photothermal therapy from magnetoliposomes and lactoferrin’s potent anticancer activity is anticipated to yield a targeted and enhanced therapeutic effect.
