Author(s): Cardoso, Elsa M. ; Gomes, Vânia Lourenço ; Esgalhado, André J. ; Ferreira, Débora Reste ; Oliveira, Nádia ; Amaral, Ana Saraiva ; Martinho, António ; Gama, Jorge ; Verde, Ignacio ; Lourenço, Olga ; Fonseca, Ana C. ; Buchli, Rico ; Arosa, Fernando A.
Date: 2023
Persistent ID: http://hdl.handle.net/10400.6/13396
Origin: uBibliorum
Subject(s): Alzheimer's; Biomarkers; Dementia; Immunoregulation; Neurodegeneration; Parkinson's; MHC; Soluble HLA class I
MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/predementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA-A23/A24 and dementia. HLA-A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA-A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA-A23/HLA-A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers.
