Author(s): Brilhante, Raimunda Sâmia Nogueira ; Valente, L. G. A. ; Rocha, Marcos Fábio Gadelha ; Bandeira, Tereza de Jesus Pinheiro Gomes ; Cordeiro, Rossana de Aguiar ; Lima, Rita Amanda Chaves de ; Leite, João Jaime Giffoni ; Ribeiro, Joyce Fonteles ; Castelo-Branco, Débora de Souza Collares Maia ; Monteiro, Andre Jalles ; Sidrim, José Júlio Costa ; Pereira, J. F.
Date: 2013
Origin: Oasisbr
Subject(s): beta-Lactamas; Burkholderia
This study aimed to evaluate the in vitro combination of farnesol and -lactams against Burkholderia pseudomallei . A total of 12 -lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 M. The combination of this compound with -lactams resulted in statistically significant -lactam MIC reduc- tion ( P < 0.05). This study provides new perspectives for the use of farnesol combined with -lactam antibiotics against strains of B. pseudomallei.
